What Are the Side Effects of Meal Replacement Shakes?
What are the side effects of meal replacement shakes? Learn about the meal replacement ingredients most likely to cause side effects.
Meal Replacement Shake Side Effects
Do Meal Replacement Shakes Cause Side Effects?
Meal replacement side effects, also known as adverse reactions, are unwanted symptoms caused by the consumption of meal replacement shakes.
Common examples include acne, headaches, and digestive distress.
The last one is really common, that is, roughly 1 in 5 people experience bloating, constipation, diarrhea, gas, nausea, and/or stomach pain after drinking meal replacement shakes.
Keep in mind that severity and duration of side effects varies from person to person.
Why Do Meal Replacements Cause Adverse Reactions?
If a meal replacement causes side effects, the reason why can usually be found on the ingredient list.
Here are some of the most common side effects and problematic ingredients to avoid:
Acne
Meal replacements made with whey and/or casein are notorious for making people break out.
Dairy-based proteins can stimulate the production of insulin and insulin-like growth factor, both of which have been linked to acne development.
Although this link is not fully understood, it likely has something to do with the fact that insulin production regulates sebum production.
Sebum, an oily, waxy substance produced by your body’s sebaceous glands, can clog your pores and cause pimples.
Headaches
Meal replacement shakes are known to cause headaches or even migraines.
Here are some of the ingredients that may be the problem:
- Caffeine: Caffeine is a common headache trigger, so if you are sensitive to caffeine, you may want to avoid chocolate, coffee, and matcha-flavored protein powders.
- Sugar: Some protein powders contain lots of added sugar, which can cause spikes and crashes in blood glucose levels, leading to headaches.
- Dairy: Protein supplements made with whey or casein, can trigger a histamine response in certain individuals. This can lead to headaches, particularly in those who are histamine intolerant.
- Artificial sweeteners: For some people, the culprit may be artificial sweeteners. Although it is hard to say that there is a definitive connection between headaches and artificial sweetener consumption, a few studies have demonstrated a link.
Certain food additives can also trigger headaches and even migraines, so it is best to look for a short list of simple ingredients.
Digestive Issues
Among these meal replacement ingredients known to cause digestive side effects are food additives like emulsifiers, thickeners, and flavors.
Ultra-processed additives like these can cause bloating, constipation, diarrhea, and stomach pain.
They can also alter the composition of your gut microbiome.
This can lead to gut dysbiosis, or an imbalance in gut bacteria, which is linked to the development of chronic digestion problems like irritable bowel syndrome (IBS).
Because your gut microbiome affects various physiological processes, including immune function and inflammation, when the balance of bacteria therein is disrupted, it can have a huge impact on your digestive health.
Here is a list of the most common food additives in meal replacements:
- acacia fiber
- acacia gum
- acesulfame potassium
- artificial flavors
- ascorbic acid
- aspartame
- calcium carbonate
- carrageenan
- cellulose gum
- dextrin
- dicalcium phosphate
- dipotassium phosphate
- erythritol
- gellan gum
- guar gum
- gum arabic
- inulin
- locust bean gum
- maltitol
- maltodextrin
- mono- and diglycerides
- ‘natural’ flavors
- rice bran extract
- rice dextrin
- rice hulls
- rosemary extract
- silica
- silicon dioxide
- sodium alginate
- soluble corn fiber
- sorbitol
- soy lecithin
- sucralose
- sunflower lecithin
- tocopherols
- tricalcium phosphate
- xanthan gum
- xylitol
- zinc oxide
Note that this list includes several artificial sweeteners.
Artificial sweeteners like sucralose and acesulfame potassium are among the worst ingredients for your gut microbiome.
They both reduce microbial diversity and promote the growth of potentially pathogenic bacteria.
In short, if you could not find an ingredient in nature or make it at home, it should not be in your meal replacement.
If you have a sensitive stomach, you should also avoid dairy-based proteins like whey and casein, which contain lactose, a sugar most adults cannot fully digest.
Keep in mind that you may be sensitive to dairy-based proteins even if you are not lactose intolerant.
This is particularly true for casein protein, which forms a gel-like substance in your stomach that slows down digestion.
Finally, you should steer clear of protein concentrates and isolates.
Protein concentrates and isolates have been mechanically and/or chemically stripped of everything but the protein, including the enzymes, fiber, and other natural digestive aids that help you break them down.
You therefore do not digest them in the same way that it does whole foods, which can affect everything from satiety to gut health.
In fact, studies show that regularly eating protein concentrates and isolates can disrupt your gut microbiome and cause the formation of toxic byproducts in your gut.
So, pending further research, it is recommended that you stick to meal replacements made from whole food protein sources.

Drink Wholesome Does NOT Cause Side Effects
Finding a meal replacement free from food additives, dairy-based proteins, and protein concentrates and isolates is hard.
In fact, 99% of meal replacements contain one or more of these problematic ingredients, which is why we created Drink Wholesome.
Our Meal Replacement Powders do not cause side effects because they are made from a short list of simple ingredients.
Our Ingredients

collagen

almonds

oats

coconut

monk fruit

vanilla
NOT Our Ingredients
acacia gum
acesulfame potassium
artificial flavors
carrageenan
erythritol
guar gum
inulin
maltodextrin
'natural' flavors
silica
soy lecithin
sucralose
xanthan gum
xylitol
Note that instead of using protein concentrates or isolates, we use whole food protein sources like almonds, which are easier to digest and absorb.
It follows that our customers experience fewer digestive issues with our Meal Replacement Powders than with any other type of meal replacement.
Order Samples to see for yourself.
Reviews
Cheryl
3 months ago
Verified Purchase I have acid reflux and your product was recommended for people like me. I ordered it and I love it! It is so clean and I digest it so well. Keep doing what you are doing...you are on the right track! acid reflux
Anne
5 months ago
Verified Purchase I had gum surgery and need soft foods/liquid type for at least 30 days. Finding a drink that had wholesome ingredients wasn’t easy! So glad I stumbled upon yours! Love both the choc and vanilla with my almond milk or water from my Berky water filter. I’ll be a customer for life! Thanks for doing the research and creating something healthy!
Jake
7 months ago
Verified Purchase I was recently diagnosed with Graves disease and Drink Wholesome has been an important part of my wellness journey. This isn't quite the product I was looking for, but it's a lot better than the alternatives. I'd love to see a higher calorie version...
Frequently asked questions
Who is Drink Wholesome for?
Drink Wholesome is the best meal replacement powder for sensitive stomachs. Because it’s made from a short list of simple ingredients, it’s also a great option for anyone who wants to avoid artificial and ultra-processed ingredients – including kids, seniors, and moms.
Why is Drink Wholesome easy to digest?
No Dairy
Drink Wholesome is made without whey and casein, which contain lactose, a sugar most people can’t fully digest. Dairy-based proteins, especially casein, also form a gel-like substance in your stomach, which can upset sensitive stomachs.
No Additives
Drink Wholesome is made without food additives. Regularly eating artificial sweeteners, emulsifiers, thickeners, and other additives can cause digestive issues and even long-term gut health problems.
Whole Food Protein
Drink Wholesome is made from whole food protein sources like almonds and egg whites. Unlike ultra-processed protein concentrates and isolates, which have been stripped of fiber, enzymes, and other natural digestive aids, whole foods are easy to break down and absorb.
Protein powder vs meal replacement powder?
We make Protein Powders and Meal Replacement Powders for sensitive stomachs. Protein powder is high in protein and low in everything else, whereas meal replacement powder contains fats, carbs, fiber, and protein because it’s intended to replace the nutritional value of a light meal.
Ask our dietitian.
If you’re wondering which of our products is best for you, ask our registered dietitian. He’ll reply via email within 24 hours.
High Protein Blueberry Pancakes
PREP TIME
5 min
COOK TIME
5 min
SERVES
2
Ingredients
- ¼ cup Drink Wholesome
- ⅓ cup flour
- 2 egg whites
- ¼ cup plant milk
- 1 tbsp nut butter
- 2 tbsp maple syrup
- 1 cup blueberries
Instructions
In a blender, combine the egg whites, milk, ¼ cup blueberries, and almond butter. Pour the mixture into a small mixing bowl and add the protein powder and flour. Whisk until smooth. Pour ⅓ cup batter onto a heated and greased (or non-stick) pan to form pancakes. Cook each side for 2-3 minutes. This recipe makes 4-5 pancakes. Then, in a small saucepan, heat ¾ cup blueberries and the maple syrup over medium heat, stirring occasionally, for about 8 minutes. Plate the pancakes and spoon blueberry jam on top.






