What Is the Best Protein Powder for Depression?


Are you looking for the best protein powder for depression? Discover how protein powder can affect your mental health.

Protein Powder for Depression

Can Protein Powder Cause Depression? 


You may have read that protein powder can cause depression, which is not true.

No clinical evidence that supports an correlation or even association between protein powder consumption and depression.

Almost everyone who claims that there is a link between protein powder consumption and depression cites the same study conducted by the University of Sydney.

In this study, researchers examined the relationship between dietary branched-chain amino acids (BCAAs) and overall health, and found that long-term dietary BCAA manipulation influences health and lifespan in mice.

Note that his study involved mice, not humans.

The notion that protein powder can cause depression in humans is therefore an extrapolation of animal data to humans.

And the assessment of human response from animal data is significantly limited, so using this study to make claims about human health is problematic to say the least.

a man and a woman making a protein shake with drink wholesome protein powder

Moreover, anyone who uses this study to suggest that protein powder causes depression in humans does not understand what BCAAs are.

Branched chain amino acids (BCAAs) are a group of 3 amino acids: valine, leucine, and isoleucine.

They are in most of the foods that we eat, not just in protein powders.

To say that protein powder, because it contains BCAAs, causes depression is therefore silly.

If BCAAs were really the issue, then any dietary protein sources could make us depressed.

Finally, the study in question mentions depression only once, and the researchers were referring to existing literature, not their own findings

In short, protein powder itself will not make you depressed.

That said, some common protein powder ingredients could affect your mental health.

a man making a protein shake with drink wholesome protein powder

What Is the Best Protein Powder for Depression?


As long as you are eating a balanced diet, the type (egg, pea, whey, etc.) of protein powder you use does not matter.

Ingredients do matter, however.

Many protein powders contain ingredients that could contribute to mental health problems.

Among these ingredients are food additives and protein concentrates/isolates.

Avoid Food Additives

Regularly eating food additives like emulsifiers, thickeners, and flavorings can alter the composition and function of your gut microbiome.

This, in turn, can lead to gut dysbiosis, which research shows can affect your mental health and contribute to mental disorders such as anxiety and depression. 

This is all possible due to a bidirectional pathway between your gut and brain called the gut-brain axis.

Here is a list of the most common food additives in protein supplements:

  • acacia fiber
  • acacia gum
  • acesulfame potassium
  • artificial flavors
  • ascorbic acid
  • aspartame
  • calcium carbonate
  • carrageenan
  • cellulose gum
  • dextrin
  • dicalcium phosphate
  • dipotassium phosphate
  • erythritol
  • gellan gum
  • guar gum
  • gum arabic
  • inulin
  • locust bean gum
  • maltitol
  • maltodextrin
  • mono- and diglycerides
  • ‘natural’ flavors
  • rice bran extract
  • rice dextrin
  • rice hulls
  • rosemary extract
  • silica
  • silicon dioxide
  • sodium alginate
  • soluble corn fiber
  • sorbitol
  • soy lecithin
  • sucralose
  • sunflower lecithin
  • tocopherols
  • tricalcium phosphate
  • xanthan gum
  • xylitol
  • zinc oxide

Basically, if you could not find an ingredient in nature or make it at home, it should not be in your protein powder. 

Avoid Protein Concentrates and Isolates

The protein source itself (not the type of protein, but the form) might be a factor worth considering too.

Most protein supplements are made from protein concentrates and isolates, which have been mechanically and/or chemically stripped of everything but the protein.

This includes the enzymes, fiber, and other natural digestive aids that help your gut break them down.

You therefore do not digest them in the same way that it does whole foods, which can affect your gut health.

In fact, studies show that regularly eating protein concentrates and isolates can disrupt your gut microbiome and cause the formation of toxic byproducts in your gut.

So, pending further research, it is recommended that you stick to protein powders made from whole food protein sources.

Drink Wholesome Is the Best Protein Powder for Depression

Finding a protein powder free from food additives and protein concentrates and isolates is hard.

In fact, 99% of protein supplements contain one or more of these problematic ingredients, which is why we created Drink Wholesome.

We make the best protein powder for depression because we use a short list of simple ingredients.

Our Ingredients

egg whites

egg whites

coconut

coconut

vanilla

vanilla

monk fruit

monk fruit

NOT Our Ingredients

  • acacia gum

  • acesulfame potassium

  • artificial flavors

  • carrageenan

  • erythritol

  • guar gum

  • inulin

  • maltodextrin

  • 'natural' flavors

  • silica

  • soy lecithin

  • sucralose

  • xanthan gum

  • xylitol

Note that instead of using protein concentrates or isolates, we use whole food protein sources like egg whites and almonds, which are easier to break down and absorb.

It follows that our customers experience fewer digestive issues with our Protein Powder more than any other protein supplement.

Order Samples to see for yourself.

Reviews

Gabriella

3 weeks ago

Verified Purchase As someone who has struggled with chronic conditions for 10+ years, getting in nutrient-dense foods is big part of how I care for my body. Finding options that are tasty and convenient is difficult. And I am always trying to eat enough in order to maintain my weight. Providers consistently recommend smoothies/shakes. I have tried so many over the years and each time the GI symptoms are intense or the flavor is awful! Since finding Drink Wholesome, I have finally been able to incorporate higher protein smoothies and shakes without the digestive upset. As a result, I have been able to maintain my weight more easily and even gain some beneficial weight. digestive issues

For Egg White Protein Powder

Gayle

2 months ago

Verified Purchase Drink Wholesome is really the best handful of ingredients protein powder that didnt give me any stomach issues at all. Anyone who has had bloat, etc should try this protein powder. I’ve been making smoothies since April 2025 and no problems at all. bloating

For Egg White Protein Powder

Matt

2 months ago

Verified Purchase After trying so many protein options and trying to live well with IBS on the go and staying fit and healthy in my 50s, I can honestly say what you are doing at Drink Wholesome is great. Keep up the great work, keep it simple and clean, and keep it positive like you have been. It’s refreshing and it works. Thank you. IBS

For Egg White Protein Powder

Frequently asked questions

Who is Drink Wholesome for?

Drink Wholesome is the best protein powder for sensitive stomachs. Because it’s made from a short list of simple ingredients, it’s also a great option for anyone who wants to avoid artificial and ultra-processed ingredients – including kids, seniors, and moms.

Why is Drink Wholesome easy to digest?

No Dairy 

Drink Wholesome is made without whey and casein, which contain lactose, a sugar most people can’t fully digest. Dairy-based proteins, especially casein, also form a gel-like substance in your stomach, which can upset sensitive stomachs.

No Additives

Drink Wholesome is made without food additives. Regularly eating artificial sweeteners, emulsifiers, thickeners, and other additives can cause digestive issues and even long-term gut health problems.

Whole Food Protein

Drink Wholesome is made from whole food protein sources like almonds and egg whites. Unlike ultra-processed protein concentrates and isolates, which have been stripped of fiber, enzymes, and other natural digestive aids, whole foods are easy to break down and absorb.

Collagen vs egg white vs almond protein powder?

We make three types of Protein Powder for sensitive stomachs: Collagen Protein Powder, Egg White Protein Powder, and Vegan Almond Protein Powder. As long as you eat a balanced diet (get protein from a variety of sources), any type of protein powder can help you meet your protein needs. So just pick the type that best suits your personal preferences.

Ask our dietitian.

If you’re wondering which of our products is best for you, ask our registered dietitian. He’ll reply via email within 24 hours.

Ask Our Dietitian
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High Protein Blueberry Pancakes

PREP TIME

5 min

COOK TIME

5 min

SERVES

2

Ingredients
  • ¼ cup Drink Wholesome
  • ⅓ cup flour
  • 2 egg whites
  • ¼ cup plant milk
  • 1 tbsp nut butter
  • 2 tbsp maple syrup
  • 1 cup blueberries
Instructions

In a blender, combine the egg whites, milk, ¼ cup blueberries, and almond butter. Pour the mixture into a small mixing bowl and add the protein powder and flour. Whisk until smooth. Pour ⅓ cup batter onto a heated and greased (or non-stick) pan to form pancakes. Cook each side for 2-3 minutes. This recipe makes 4-5 pancakes. Then, in a small saucepan, heat ¾ cup blueberries and the maple syrup over medium heat, stirring occasionally, for about 8 minutes. Plate the pancakes and spoon blueberry jam on top.

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